Review About The Latest Most Powerful Supplement for Treatment of Impotence and Premature Ejaculation

Just like the introduction of Viagra to the public some years ago, it brought about its own revolution; millions of men sought and received prescriptions of it for the treatment of impotence. The rush for this medication and physicians' willingness to dispense it mark a sea change in how people view the condition, which for decades was considered to be mainly of psychogenic origin.

This change has significant impact for the approximately 10 percent of the male population who will at some point in their lives faced with complete inability to achieve or maintain an erection. This condition, which becomes more prevalent with age, has the effect of making sexual intercourse difficult, if not impossible.

 Although proved medical interventions have been available for more than 20 years before then, but recent advances in the understanding of the processes that lead to an erection have spurred new treatments and promise even more targeted therapies in the years to come.

Nevertheless, before the advent of modern therapies, erectile dysfunction was often treated through psychoanalysis, if treated at all. Now cases can be diagnosed as having organic causes, including nerve damage, hormonal imbalance and vascular disease. The shift in diagnoses from psychogenic to organic has moved the primary responsibility for treating patients from psychiatrists to urologists and now naturopathy. 

And this recently shift has spurred the manufacture and introduction of ExtenZes male sex enhancer supplement to the marketplace; a natural health supplement that is made with the finest herbal ingredients for the treatment of erectile dysfunction (impotence) and premature ejaculation (PE), that now allow men treat cases of erectile dysfunction without prescription or over the counter dispensed drugs.

Now, understanding of the penis’s erectile mechanism have allows us to treat the organic causes of male organ dysfunction in many ways and ExtenZe herbal supplement has become a catchall cure for the modern man. The famous herbal pill is now the treatment of choice in approximately 90 percent of erectile dysfunction and quick ejaculation cases in Europe, Australia and America, even Africa.

However, this development has raised some confusion since there are other herbal products in the market today claiming to enhance male sexuality, and they are laden with chemicals that make them unsafe for human use. Even the natural health product is infiltrated with substandard and poseur products in the market, claiming to treat sexual dysfunctions. 

In this review however, I do not intend to compare ExtenZe to any other product in this category, but to introduce it to the audience for those that have not known about it, knowing very well that it is very effective for the treatment of premature ejaculation, erectile dysfunction and low libido. 

Penile Anatomy

To understand the causes of erectile dysfunction, you must first know something about the anatomy of the penis. The organ's functions, of course, are to enable urine to exit the body and, when rigid, to help introduce sperm into the vaginal canal.

An erection, however, is not necessary for impregnation of a female partner, because orgasm and ejaculation can occur in a semi-rigid state; the penis contains three well-vascularized cylinders of spongy tissue: the two corpora cavernosa and the corpus spongiosum. 

The latter has in its center the urethral channel, a tubular structure lined with specialized flattened cells through which urine passes, the three cylinders act as draining pools for the penis's blood supply, and produces an erection when they engorged. Smooth muscle and nerve beds line the entire phallus.

Blood flows toward the penis from the two pudendal arteries, which emerge from the pelvis and then separately fork into two smaller branches - the dorsal and cavernous arteries, which run into the penis. Because the pudendal artery passes through the region between the anus and the base of the scrotum before reaching the penis, it is particularly vulnerable to injuries such as pelvic fracture or trauma from falling onto a post or bicycle bar.

 The two branches of the pudendal artery branch off into smaller arteries once inside the penis, decreasing to a diameter of only 0.4 millimeter when the penis is flaccid. These relatively narrow blood vessels are susceptible to blockage from various arterial-narrowing conditions such as hypertension and atherosclerosis.

The high incidence in our society of cardiovascular disease, which is exacerbated by diabetes, inflammation, bacterial infection, alcohol and smoking, causes diminished blood flow to the penis the most common cause of organic erectile dysfunction.

Three primary types of cells live in the tissue of the penile corpora cavernosa, and they are endothelial, smooth muscle and neurons. Endothelial cells line blood vessels and the sinusoids—the spaces within the corpora cavernosa—and secrete substances that aid in the relaxation and contraction of adjacent smooth muscle cells.

The penis has two states, flaccid and erect. The difference between the two depends on the filling of the penile chambers with blood up to the level of pressure in the major arteries of the body. If not sexually active, normal men are flaccid about 23 hours of the day, with approximately one aggregate hour of erection occurring during a part of rapid eye movement (REM) sleep. 

Men average four or five REM erections a night, each lasting about 15 minutes, although the cause and function of these erections are not yet known, but the frequency of REM erections usually diminishes with age. The number and duration of daytime erections for sexually active men varies greatly from person to person.

The Science of Stimulation

Most men do not walk around with a constant erection; this is because of the brain's inhibitory control over the erectile mechanism. Then, when that control is suddenly removed, as in the case of a hanging, a spontaneous erection sometimes occurs. Then, it needs a stimulus to begin the process. 

And this sexual signal can be visual, tactile, auditory, gustatory or olfactory, or it may arise during dream-associated sleep. Conscious or unconscious neurological signals originating in the cerebral cortex, and limbic system sent to the hypothalamus and relayed down the spinal cord into the sympathetic and parasympathetic neurons of the penis.

The nerve endings then releases neurotransmitters that relax the smooth muscle cells lining the corporal bodies and the arteries supplying blood to the penis, when more blood enters than exits, then the penis becomes rigid. The entire sequence of events, from stimulation to erection, can take place in seconds.

Many types of nerves and molecules participate in the signal transmission that culminates in an erection. The primary pathway is through autonomic nerve fibers that releases molecules of nitric oxide near the smooth muscle cells of the penis. The nitric oxide diffuses through the cell membranes and begins a chemical cascade that culminates in the relaxation of the cells.

The secondary pathway is through cholinergic nerves, which release the neurotransmitter acetylcholine. This chemical stimulates endothelial cells to produce nitric oxide, which then seeps into the adjacent smooth muscle cells. However, the most abundant nerves in the penis are actually adrenergic fibers, which provide brakes to the erection process in the absence of stimulation.

In addition to the signals along the autonomic nerves to the penis, hormones entering the sinusoids and penile tissues during flaccidity provide regulatory signals. Hormones such as noradrenaline secreted from the adrenal glands and testosterone from the testes help to regulate the tone of the corporal smooth muscles and the secretory capacity of certain nerve fibers.

Causes of Dysfunction

Anything that interferes with the nerve pathway can cause erectile dysfunction, Trauma such as head and spinal cord injuries, stroke, Parkinson's disease, and diseases with systemic effects such as multiple sclerosis and diabetes can diminish nerve function and lead to impotence.

Aging can be contributory, because is often accompanied by a decrease in penile nerve endings and blood flow and by an increase in smooth muscle cell tone, making achieving an erection more difficult. Certain medications and alcoholism can also cause impotence. 

Vascular conditions such as hardening of the arteries can damage vessels supplying blood flow to the penis. Furthermore, anything that influences the primitive hypothalamic regions responsible for libido has the potential to cause erectile dysfunction. These factors include aging, depression, anxiety, chronic illness and medications that affect the central nervous system.

Finally, our new understanding of the erection process does not rule out the presence of secondary psychological problems emerging because of erectile dysfunction, which are often incorrectly blamed for the condition. In addition, certain psychological conditions, such as anxiety disorders, can be the primary cause of impotence.

The earliest effective treatment for organic impotence was the penile implant, successfully performed for the first time in 1947 using a single rigid plastic strut that was surgically inserted into the penis. Previous surgical efforts using a piece of rib or cartilage had failed because of rapid breakdown and absorption of the implant by the body.

At a time, the plastic strut allowed some men to resume coitus, the introduction of medical-grade silicone in the 1960s that ushered in a truly practical surgical solution. In which the single flexible silicone rod was quickly followed by the introduction of more anatomically correct semi-rigid rods that bend like pipe cleaners, allowing manual positioning of the penis into an erection.

Soon afterward, a three-component inflatable device was designed, the components include a bulb placed inside the scrotum, an inflatable cylinder positioned inside the penis and a saline sack inserted into the abdomen. Pumping of the bulb causes fluid to fill the cylinder, bringing about rigidity. And a release valve in the bulb allows a return to the flaccid state. 

Before now, many companies in the U.S. and other countries have manufactured a variety of semi-rigid and inflatable prosthetic devices.

The average age of a patient choosing a prosthetic is 50, and the implants seldom wear out, even after decades of use; each implant carries a manufacturer's lifetime guarantee. Implants are safe and almost 100 percent effective.

In addition, the approach offers a particular advantage not present in any other impotence treatment at the time, and it allows coitus without prior planning. That fact greatly increases the overall satisfaction of the men and their partners who choose this option.

Another mechanical treatment is a vacuum pump, a temporary, nonsurgical approach that works on the same principle as milking machines placed over a cow's udder. Pumping air out of an airtight chamber covering the penis and creates a vacuum, which draws blood into the penile sinusoids. 

A tourniquet is placed at the base of the penis to trap the blood in the phallus after removal of the vacuum chamber. Though safe, the instrument produces varying degrees of penile rigidity for each man and during each episode of use.

Penile Injections

The next major treatment advance was hit on by serendipity: in 1979 French vascular surgeon, Ronald Virag accidentally injected papaverine rather than saline into a patient's penis during a diagnostic procedure. 

To his, and probably the patient's surprise, the man became erect; Virag quickly recognized the utility of papaverine, a drug used to induce smooth muscle relaxation. After confirming the reproducibility of triggering an erection, which occurred minutes after intracorporal injection of the drug, then he announced his findings.

This discovery highlighted for the first time that smooth muscle relaxation was the key erectile mechanism and set the direction for the next generation of basic research. Of particular interest is that papaverine acts very far down in the chemical cascade needed for erection by increasing the concentration of cyclic adenosine monophosphate (cAMP), a chemical that helps to block the entry of calcium ions into the cell, which in turn results in smooth muscle relaxation.

 Activity at this point in the erectile process negates the need for sexual excitement in achieving erection. This discovery made available an inexpensive, safe, repeatable treatment that was effective in a very high percentage of men with diverse origins of impotence.

Other injectable agents soon followed, each affecting the erectile mechanism at different points in the signaling process. The drug phentolamine induces erections by blocking norepinephrine. Prostaglandin induces cAMP production, which then causes cell relaxation in the same way as papaverine. 

Because these drugs act at different points in the erection process, they can act to optimize one another's effects. Researchers have taken advantage of this, and now combinations of the drugs are widely used as an intracavernous injectable mixture.

Although these injectable drugs are effective in about 80 percent of patients, they require some advance planning, as there is about a 10-minute waiting period before erection. In addition, side effects, which are seen in a very small percentage of users, can include corporal scarring and penile pain. The most significant disincentive for their use, however, appears to be the psychological barrier to self-injection.

The inclusion of injectable treatments in the recommendations of a 1992 National Institutes of Health conference on impotence helped to legitimize the treatment of erectile dysfunction in the eyes of the government. Subsequent approval by the Food and Drug Administration of Caverject - an intracavernous injection of prostaglandin and MUSE, a prostaglandin intraurethral pellet that brought about Medicare reimbursement for some nonsurgical treatments of erectile dysfunction.

Pill Popping

In the tradition of previous erectile-dysfunction therapy discoveries, the erection-inducing effect of sildenafil, commonly known by its brand name – Viagra was discovered inadvertently. While performing clinical studies of sildenafil as a treatment for heart failure, researchers noticed that a statistically significant number of men were getting erections after taking the drug.

Knowing a good thing when they saw it, the researchers began a separate clinical program to evaluate the drug as an impotence treatment. The heart treatment protocol was eventually dropped because of a high rate of fatal arrhythmias. But as a treatment for impotence, Viagra became the fastest-selling new drug on record, registering worldwide sales of some $700 million in its first nine months on the market.

The drug works by inhibiting the degradation of cyclic guanosine monophosphate (cGMP), which is the last molecule in the chemical cascade that causes an erection. It blocks the activity of one type of phosphodiesterase, an intracellular enzyme found in vascular smooth muscle. 

This enzyme normally breaks down cGMP, but when it inhibits the enzyme, the cGMP remains active, and the signal for smooth muscle relaxation is left in the 'on' position. The drug is effective in inducing erection in about 70 percent of men, as long as they have healthy penile blood flow, intact nerves and sufficient capacity to produce nitric oxide, a precursor to cGMP production.

Because the drug is dependent on nitric oxide release, which is a result of nerve signals to the penis, sexual stimulation must occur for an effect to be seen, Viagra acts not only on penile tissue but also throughout the body, potentially causing dose-related side effects such as facial flushing, headaches, gastrointestinal distress and a blue tinge to vision. 

In addition, it must be taken on an empty stomach and without alcohol; some advance planning is needed because the drug does not take effect until up to an hour after pill ingestion. The major drawback with the medication may be the possibility of death: the FDA reported approximately 130 U.S. deaths were potentially related to the use of Viagra in the first eight months that the drug was on the market.

Although it can be argued that this represents a very small percentage of the men who have taken the drug, but there was almost no reports of death with the other therapies for penile dysfunction. Moreover, the drug has affected more than just the treatment of impotence: it has changed the way impotence condition was diagnosed.

Just like what I said in the first paragraph of this post, before the advent of drugs, folk medicine and naturopathic healers have had a variety of natural and botanical ingredients in their arsenal of tools to combat impotence due to depression, anxiety, chronic illness etc. that affect the central nervous system aging, hormonal imbalance or emotional upset.

What is new now is the availability of these herbs in specialized, pre-calibrated formulas in new standardized dosages, without any side effect. It is obvious that the male sex organ has past through its tempest time and we are now in the age of using herbal and effective method of solving impotence problem in the world.

The good news is that ExtenZe herbal delivers, it is all-natural libido booster and sex enhancement supplement for men, it's got a quality formula that helps men hit their potential in the bedroom regardless of age and ensures enough sexual activity to keep the neighbors awake (probably more than they'd like!).

Being a natural male enhancement product, the ingredients in ExtenZe need time to build up in your system. There is usually a waiting period between one and three months before natural male enhancers deliver those noticeable increases to sex drive you are looking for. However, many guys have confirmed that ExtenZe is one of the faster supplements and they're often pleasantly surprised with the spike in sexual activity in the first month.

What Users Like About ExtenZe:

It is a good product, is an all-natural supplement that gives men the ability to have spontaneous sex, no awkward waiting period for a little blue pill to kick in. Once the nutrients in ExtenZe have cumulated in your body, it is playtime. Whenever and as often as you like, you may also last longer.

Most users buy the product because it is so famous; they have seen it on TV and read about it. The recognition factor is important for them, and if that matters to you, this is a good product. The product also offers very good value when you buy it through the appropriate channels. We will discuss that in a bit.

What Users Don't Like About ExtenZe:

It is obvious that it works for the vast majority of guys and most of them love it, admittedly, though, it is not the most powerful formula when compared to a few other male enhancement products, which remain a little more 'exclusive'.

Some guys aren't keen on waiting up to three months to enjoy the benefits of ExtenZe either but it worth a trial, and if you actually want to get good value for your money, I suggest you buy it in package that comes with free personal lubricants, to offer instant arousal while your body processes the nutrients in the supplement.

Ingredients:

ExtenZe is good and natural, it has a nice variety of herbals and amino acids, like l-arginine, pumpkin seed and ginger. However, some guys love that it has yohimbe extract, but others prefer their enhancers to be yohimbe-free.

As I said earlier, the product formula is not as strong as a few of the most exclusive enhancement products, but there is more than enough here to have your libido firing on all cylinders. Being natural, most guys buy it to avoid that whole mess of prescription ED pills. ExtenZe is a winner, with all-natural ingredients that are well-tolerated and with very minimal report of side effects.

Value:

ExtenZe offers good value, but you will get BETTER value when you buy it at buyextenze.com, and you need to take it at least six months to get the most enjoyment and performance out of the product because your body needs time to process the nutrients, since herbs do not act like chemicals. 

Moreover, it is on this reason buyextenze.com, offers discount packaging on larger orders, bringing the cost down to about half of what you would pay if you bought it in a store. No worrying about prying eyes either, and they will ship it free within the United States if you buy a 6 month package or higher.

Nevertheless, maybe the best reason to buy ExtenZe at that site is that they give you a free bottle of personal lubricant on orders of three months or higher. And the bottles are HUGE... and the reports coming in are that it feels amazing, the bigger package you buy, the more free bottles you get.

Final Word On ExtenZe:

Send the kids away. You are going to be very busy with ExtenZe - and busier when you buy it at buyextenze.com because of those free bottles of ExtenZe lube. ExtenZe offers credibility, value, and yeah, it really works all good reasons to put ExtenZe in your life.